|Title||Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)|
|Journal||American Heart Journal|
|Authors||Omar M. Issa, DO, Rhonda Roberts, MPH, Daniel B. Mark, MD, MPH, Robin Boineau, MD, Christine Goertz, DC, PhD, Yves Rosenberg, MD, MPH, Eldrin F. Lewis, MD, Erminia Guarneri, MD, Jeanne Drisko, MD, Allan Magaziner, DO, Kerry L. Lee, PhD, Gervasio A. Lamas, MD|
|Link to article|
In a prespecified subgroup analysis of participants not on statin therapy at baseline in the TACT, a high-dose complex oral multivitamins and multimineral regimen was found to have a large unexpected benefit compared with placebo. The regimen tested was substantially different from any vitamin regimen tested in prior clinical trials. High-dose oral multivitamin and multimineral supplementation seem to decrease combined cardiac events in a stable, post-MI population not taking statin therapy at baseline. These unexpected findings are being retested in the ongoing TACT2.