| Title | Cadmium level and severity of peripheral artery disease in patients with coronary artery disease |
| Journal | European Journal of Preventive Cardiology |
| Authors | Ujueta, F., Arenas, I. A., Diaz, D., Yates, T., Beasley, R., Navas-Acien, A., & Lamas, G. A. |
| Year Published | 2019 |
| Link to article | |
Publications
Edetate Disodium-Based Treatment in a Patient With Diabetes and Critical Limb Ischemia After Unsuccessful Peripheral Arterial Revascularizations: A Case Report
| Title | Edetate Disodium-Based Treatment in a Patient With Diabetes and Critical Limb Ischemia After Unsuccessful Peripheral Arterial Revascularizations: A Case Report |
| Journal | Clinical Diabetes |
| Authors | Ujueta, F., Arenas, I. A., Yates, T., Beasley, R., Diaz, D., & Lamas, G. A. |
| Year Published | 2019 |
| Link to article | |
Potential Role of Metal Chelation to Prevent the Cardiovascular Complications of Diabetes
| Title | Potential Role of Metal Chelation to Prevent the Cardiovascular Complications of Diabetes |
| Journal | Clinical Endocrinology and Metabolism |
| Authors | Calderon Moreno, R., Navas-Acien, A., Escolar, E., Nathan, D. M., Newman, J., Schmedtje, J. F., Diaz, D., Lamas, G. A., & Fonseca, V. |
| Year Published | 2019 |
| Link to article | |
Abstract
For decades, there has been epidemiologic evidence linking chronic toxic metal exposure with cardiovascular disease, suggesting a therapeutic role for metal chelation. Given the lack of compelling scientific evidence, however, the indications for metal chelation were never clearly defined. To determine the safety and efficacy of chelation therapy, the National Institutes of Health funded the Trial to Assess Chelation Therapy (TACT). TACT was the first double-blind, randomized, controlled trial to demonstrate an improvement in cardiovascular outcomes with edetate disodium therapy in patients with prior myocardial infarction. The therapeutic benefit was striking among the prespecified subgroup of patients with diabetes.
The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT)
| Title | The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT) |
| Journal | Diabetes and its Complications |
| Authors | Ujueta, F., Arenas, I. A., Escolar, E., Diaz, D., Boineau, R., Mark, D. B., Golden, P., Lindblad, L., Kim, H., Lee, K. L., & Lamas, G. A. |
| Year Published | 2019 |
| Link to article | |
Abstract
Approximately 1 in 7 US adults have diabetes; and over 60% of deaths in patients with diabetes have cardiac disease as a principal or contributing cause. Both coronary and peripheral artery disease (PAD) identify high-risk cohorts among patients with diabetes. We have previously demonstrated improved cardiovascular outcomes with edetate disodium-based chelation in post-MI patients with diabetes, enrolled in the Trial to Assess Chelation Therapy (TACT). In these analyses we further studied the effect size of patients with diabetes and severe disease in 2 vascular beds; coronaries, and lower extremity arteries. We questioned whether greater atherosclerotic burden would attenuate the observed beneficial effect of edetate disodium infusions.
Edetate disodium–based treatment in a patient with diabetes and critical limb ischemia after unsuccessful peripheral arterial revascularizations: A case report
| Title | Edetate disodium–based treatment in a patient with diabetes and critical limb ischemia after unsuccessful peripheral arterial revascularizations: A case report |
| Journal | Clinical Diabetes |
| Authors | Ujueta F, Arenas IA, Yates T, et al. |
| Year Published | 2019 |
| Link to article | |
Environmental toxic metal contaminants and risk of cardiovascular disease
| Title | Environmental toxic metal contaminants and risk of cardiovascular disease |
| Journal | British Medical Journal |
| Authors | Chowdhury R, Ramond A, O’Keeffe LM, et al. |
| Year Published | 2018 |
| Link to article | |
Conclusion
Exposure to arsenic, lead, cadmium, and copper is associated with an increased risk of cardiovascular disease and coronary heart disease. Mercury is not associated with cardiovascular risk. These findings reinforce the importance of environmental toxic metals in cardiovascular risk, beyond the roles of conventional behavioral risk factors.
Cadmium level and severity of peripheral artery disease in patients with coronary artery disease
| Title | Cadmium level and severity of peripheral artery disease in patients with coronary artery disease |
| Journal | European Journal of Preventive Cardiology |
| Authors | Ujueta F, Arenas IA, Diaz D, et al. |
| Year Published | 2018 |
| Link to article | |
Abstract
Coronary artery disease (CAD) and peripheral artery disease (PAD) both share similar risk factor profiles, representing a high disease burden and cost worldwide. Yet the preferential development of CAD, PAD, or both in individual patients is not fully understood. As part of a study of toxic metals in patients with vascular disease, we explored toxic metal profiles in three principal diagnoses: CAD, PAD, and PAD with critical limb ischemia (CLI). CLI is the most advanced form of PAD and carries a high (up to 55%) one-year risk of major vascular events. The principal target of this investigation was cadmium, a toxic atherogenic transition metal of which the principal environmental sources are smoking and diet. The present study suggests that cadmium accumulation may be a quantitative risk factor for graded development of symptomatic disease of the lower extremities, from low cadmium burden in CAD only, intermediate cadmium burden in CAD+simple PAD, and highest cadmium burden in the most severe form of PAD – CLI.
Environmental metals and cardiovascular disease
| Title | Environmental metals and cardiovascular disease |
| Journal | The BMJ |
| Authors | Tellez-Plaza M, Guallar E, Navas-Acien A |
| Year Published | 2018 |
| Link to article | |
Abstract
Editorial on a comprehensive systematic review and meta-analysis of the associations between the exposure to arsenic, lead, cadmium, mercury, and copper and the risk of cardiovascular disease.
Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis
| Title | Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis |
| Journal | The BMJ |
| Authors | Chowdhury R, Ramond A, O’Keeffe L, et al. |
| Year Published | 2018 |
| Link to article | |
Abstract
This systematic review and meta-analysis of epidemiological studies investigating the association of arsenic, lead, cadmium, mercury, and copper with cardiovascular disease concludes that exposure to arsenic, lead, cadmium, and copper is associated with an increased risk of cardiovascular disease and coronary heart disease. Mercury is not associated with cardiovascular risk. These findings reinforce the importance of environmental toxic metals in cardiovascular risk, beyond the roles of conventional behavioral risk factors.
Low-level lead exposure and mortality in US adults: a population-based cohort study
| Title | Low-level lead exposure and mortality in US adults: a population-based cohort study |
| Journal | The Lancet Public Health |
| Authors | Lanphear BP, Rauch S, Auinger P, Allen RW, Hornung RW |
| Year Published | 2018 |
| Link to article | |
Abstract
Lead exposure is a risk factor for cardiovascular disease mortality, but the number of deaths in the USA attributable to lead exposure is poorly defined. We aimed to quantify the relative contribution of environmental lead exposure to all-cause mortality, cardiovascular disease mortality, and ischaemic heart disease mortality. Our findings suggest that low-level environmental lead exposure is an important, but largely overlooked, risk factor for cardiovascular disease mortality in the USA. A comprehensive strategy to prevent deaths from cardiovascular disease should include efforts to reduce lead exposure.