Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy

Title Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy
Journal Journal of the American College of Cardiology
Authors Lamas GA, Navas-Acien A, Mark DB, Lee KL
Year Published 2016
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Abstract
This review summarizes evidence from 2 lines of research previously thought to be unrelated: the unexpectedly positive results of TACT (Trial to Assess Chelation Therapy), and a body of epidemiological data showing that accumulation of biologically active metals, such as lead and cadmium, is an important risk factor for cardiovascular disease.

Chelation therapy to treat atherosclerosis, particularly in diabetes: is it time to reconsider?

Title Chelation therapy to treat atherosclerosis, particularly in diabetes: is it time to reconsider?
Journal Expert Review of Cardiovascular Therapy
Authors Ergui I, Lamas GA
Year Published 2016
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Expert commentary
Chelation reduced adverse cardiovascular events in a post myocardial infarction (MI) population. Patients with diabetes demonstrated even greater benefit, with a number needed to treat of 6.5 patients to prevent a cardiac event over 5 years, with a 41% relative reduction in risk of a cardiac event (p = 0.0002). These results led to the revision of the ACC/AHA guideline recommendations for chelation therapy, changing its classification from class III to class IIb. TACT2, a replicative trial, will assess the effects of chelation therapy on cardiovascular outcomes in diabetic patients with a prior myocardial infarction. We are seeking participating sites for TACT2.

Enhanced Vasculotoxic Metal Excretion in Post-Myocardial Infarction Patients Receiving Edetate Disodium-Based Infusion

Title Enhanced Vasculotoxic Metal Excretion in Post-Myocardial Infarction Patients Receiving Edetate Disodium-Based Infusion
Journal Journal of the American College of Cardiology
Authors Ivan Arenas; Ana Navas-Acien; Gervasio Lamas
Year Published
2016
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Conclusions
Edetate disodium markedly increased excretion of lead and cadmium, two toxic metals with established epidemiologic evidence and mechanisms linking them to coronary and vascular events.

Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients

Title Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients
Journal Current Cardiology Reports
Authors Lamas GA, Issa, OM
Year Published 2016
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Link to abstract

Abstract
An abundance of data, known for decades, is available linking metals, such as lead and cadmium, with cardiovascular disease. However, the idea that these toxic metals could be a modifiable risk factor for atherosclerosis did not become apparent clinically until the completion of the Trial to Assess Chelation Therapy in 2012. This pivotal study was the first double-blind, randomized, controlled trial of its kind to demonstrate a clear improvement in cardiovascular outcomes with edetate disodium therapy in a secondary prevention, post-myocardial infarction population. This effect size was most striking in diabetic patients, where the efficacy of edetate disodium was comparable, if not superior, to that of current guideline-based therapies. Given the economic burden of diabetes and cardiovascular disease, the potential impact of this therapy could be enormous if the results of this study are replicated.

EDTA Chelation Therapy to Reduce Cardiovascular Events in Persons with Diabetes

Title EDTA Chelation Therapy to Reduce Cardiovascular Events in Persons with Diabetes.
Journal Current Cardiology Reports
Authors Ouyang P, Gottlieb SH, Culotta VL, Navas-Acien A
Year Published 2015
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Link to abstract

Abstract
This review discusses the epidemiologic evidence and animal and human studies supporting the role of these metals in the development of diabetes and ischemic heart disease and potential ways by which EDTA chelation could confer cardiovascular benefit.

Chelation Therapy A New Look at an Old Treatment for Heart Disease, Particularly in Diabetics

Title Chelation Therapy
A New Look at an Old Treatment for Heart Disease, Particularly in Diabetics
Journal Circulation – Cardiology Patient Page
Authors Gervasio A. Lamas, MD
Year Published 2015
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Link to abstract

Summary
Dr. Lamas provides information to patients about chelation in heart disease.

Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure

Title Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure
Journal American Heart Journal
Authors Natalia V. Solenkova, MD, PhD, Jonathan D. Newman, MD, MPH, Jeffrey S. Berger, MD, MS, George Thurston, ScD, Judith S. Hochman, MD, Gervasio A. Lamas, MD
Year Published 2014
Link to article
Link to abstract

Conclusions
There is strong evidence that xenobiotic metal contamination is linked to atherosclerotic disease and is a modifiable risk factor.