Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure

Title Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure
Journal American Heart Journal
Authors Natalia V. Solenkova, MD, PhD, Jonathan D. Newman, MD, MPH, Jeffrey S. Berger, MD, MS, George Thurston, ScD, Judith S. Hochman, MD, Gervasio A. Lamas, MD
Year Published 2014
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Conclusions
There is strong evidence that xenobiotic metal contamination is linked to atherosclerotic disease and is a modifiable risk factor.

Chelation therapy after the trial to assess chelation therapy: results of a unique trial

Title Chelation therapy and cardiovascular disease: connecting scientific silos to benefit cardiac patients
Journal Curr Opin Cardiol.
Authors Avila MD, Escolar E, Lamas GA
Year Published 2014
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Summary
Recent research suggests that EDTA chelation may be a well-tolerated and effective treatment for post-MI patients. Future replication and mechanistic studies are important prior to implementation in all post-MI patients.

Quality-of-life outcomes with a disodium EDTA chelation regimen for coronary disease

Title Quality of life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the Trial to Assess Chelation Therapy randomized trial
Journal Circ Cardiovasc Qual Outcomes
Authors Mark DB, Anstrom KJ, Clapp-Channing NE, Knight JD, Boineau R, Goertz R, Rozema TC, Liu DM, Nahin RL, Rosenberg Y, Drisko J, Lee KL, Lamas GA, of the TACT Investigators.
Year Published 2014
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Conclusions:
In stable, predominantly asymptomatic coronary disease patients with a history of myocardial infarction,EDTA chelation therapy did not have a detectable effect on QOL during 2 years of follow-up.

Chelation therapy and cardiovascular disease: connecting scientific silos to benefit cardiac patients

Title Chelation therapy and cardiovascular disease: connecting scientific silos to benefit cardiac patients
Journal Trends in Cardiovascular Medicine
Authors Peguero JG, Arenas I, Lamas GA.
Year Published 2014
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Conclusions
Among patients with a prior MI, a regimen of 40 infusions of disodium EDTA-based infusions safely reduced cardiovascular events in a post-MI population, suggesting that xenobiotic metal pollutants are cardiovascular risk factors. The effect of the chelation infusions was enhanced with high doses of oral multivitamins and multiminerals. The therapeutic benefit was particularly striking in diabetic patients. These results were observed against a background of modern evidence-based post-MI therapy.

EDTA Chelation Therapy Alone and in Combination with Oral High-Dose Multivitamins and Minerals for Coronary Disease

Title EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: the factorial group results of the Trial to Assess Chelation Therapy
Journal American Heart Journal
Authors Lamas GA, Boineau R, Mark DB, Rosenberg Y, Stylianou M, Rozema T, Nahin RL, Terry Chappell L, Lindblad L, Lewis EF, Drisko J, Lee LK
Year Published 2014
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Conclusions and Relevance:
In stable post-MI patients on evidence-based medical therapy, the combination of oral high-dose vitamins and chelation therapy compared with double placebo reduced clinically important cardiovascular events to an extent that was both statistically significant and of potential clinical relevance.