| Title | Enhanced Vasculotoxic Metal Excretion in Post-Myocardial Infarction Patients Receiving Edetate Disodium-Based Infusion |
| Journal | Journal of the American College of Cardiology |
| Authors | Ivan Arenas; Ana Navas-Acien; Gervasio Lamas |
| Year Published |
2016 |
| Link to article | |
Conclusions
Edetate disodium markedly increased excretion of lead and cadmium, two toxic metals with established epidemiologic evidence and mechanisms linking them to coronary and vascular events.
| Title | Chelation Therapy for CAD |
| Journal | American College of Cardiology |
| Authors | Gervasio A. Lamas, MD, FACC; Ian Ergui, BS; Omar M Issa, DO |
| Year Published | 2016 |
| Link to article | |
Summary
In this Expert Analysis, Dr. Lamas discuses chelation therapy and the TACT trials.
| Title | Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients |
| Journal | Current Cardiology Reports |
| Authors | Lamas GA, Issa, OM |
| Year Published | 2016 |
| Link to article | |
| Link to abstract | |
Abstract
An abundance of data, known for decades, is available linking metals, such as lead and cadmium, with cardiovascular disease. However, the idea that these toxic metals could be a modifiable risk factor for atherosclerosis did not become apparent clinically until the completion of the Trial to Assess Chelation Therapy in 2012. This pivotal study was the first double-blind, randomized, controlled trial of its kind to demonstrate a clear improvement in cardiovascular outcomes with edetate disodium therapy in a secondary prevention, post-myocardial infarction population. This effect size was most striking in diabetic patients, where the efficacy of edetate disodium was comparable, if not superior, to that of current guideline-based therapies. Given the economic burden of diabetes and cardiovascular disease, the potential impact of this therapy could be enormous if the results of this study are replicated.
| Title | Chelation Therapy A New Look at an Old Treatment for Heart Disease, Particularly in Diabetics |
| Journal | Circulation – Cardiology Patient Page |
| Authors | Gervasio A. Lamas, MD |
| Year Published | 2015 |
| Link to article | |
| Link to abstract | |
Summary
Dr. Lamas provides information to patients about chelation in heart disease.
| Title | Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure |
| Journal | American Heart Journal |
| Authors | Natalia V. Solenkova, MD, PhD, Jonathan D. Newman, MD, MPH, Jeffrey S. Berger, MD, MS, George Thurston, ScD, Judith S. Hochman, MD, Gervasio A. Lamas, MD |
| Year Published | 2014 |
| Link to article | |
| Link to abstract | |
Conclusions
There is strong evidence that xenobiotic metal contamination is linked to atherosclerotic disease and is a modifiable risk factor.
“We need more cardiologists to be thinking about environmental effects on the heart,” said Dr. Gervasio Lamas, chief of cardiology at Mount Sinai Medical Center in Miami. “It’s not just some abstract E.P.A. problem. It’s actually affecting our patients.”
| Title | Chelation therapy and cardiovascular disease: connecting scientific silos to benefit cardiac patients |
| Journal | Curr Opin Cardiol. |
| Authors | Avila MD, Escolar E, Lamas GA |
| Year Published | 2014 |
| Link to article | |
| Link to abstract | |
Summary
Recent research suggests that EDTA chelation may be a well-tolerated and effective treatment for post-MI patients. Future replication and mechanistic studies are important prior to implementation in all post-MI patients.
| Title | Quality of life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the Trial to Assess Chelation Therapy randomized trial |
| Journal | Circ Cardiovasc Qual Outcomes |
| Authors | Mark DB, Anstrom KJ, Clapp-Channing NE, Knight JD, Boineau R, Goertz R, Rozema TC, Liu DM, Nahin RL, Rosenberg Y, Drisko J, Lee KL, Lamas GA, of the TACT Investigators. |
| Year Published | 2014 |
| Link to article | |
| Link to abstract | |
Conclusions:
In stable, predominantly asymptomatic coronary disease patients with a history of myocardial infarction,EDTA chelation therapy did not have a detectable effect on QOL during 2 years of follow-up.
| Title | Chelation therapy and cardiovascular disease: connecting scientific silos to benefit cardiac patients |
| Journal | Trends in Cardiovascular Medicine |
| Authors | Peguero JG, Arenas I, Lamas GA. |
| Year Published | 2014 |
| Link to article | |
| Link to abstract | |
Conclusions
Among patients with a prior MI, a regimen of 40 infusions of disodium EDTA-based infusions safely reduced cardiovascular events in a post-MI population, suggesting that xenobiotic metal pollutants are cardiovascular risk factors. The effect of the chelation infusions was enhanced with high doses of oral multivitamins and multiminerals. The therapeutic benefit was particularly striking in diabetic patients. These results were observed against a background of modern evidence-based post-MI therapy.
Newly published research shows that chelation therapy combined with vitamins greatly reduces the risk for heart disease.