|Title||Cadmium level and severity of peripheral artery disease in patients with coronary artery disease|
|Journal||European Journal of Preventive Cardiology|
|Authors||Ujueta F, Arenas IA, Diaz D, et al.|
|Link to article|
Coronary artery disease (CAD) and peripheral artery disease (PAD) both share similar risk factor profiles, representing a high disease burden and cost worldwide. Yet the preferential development of CAD, PAD, or both in individual patients is not fully understood. As part of a study of toxic metals in patients with vascular disease, we explored toxic metal profiles in three principal diagnoses: CAD, PAD, and PAD with critical limb ischemia (CLI). CLI is the most advanced form of PAD and carries a high (up to 55%) one-year risk of major vascular events. The principal target of this investigation was cadmium, a toxic atherogenic transition metal of which the principal environmental sources are smoking and diet. The present study suggests that cadmium accumulation may be a quantitative risk factor for graded development of symptomatic disease of the lower extremities, from low cadmium burden in CAD only, intermediate cadmium burden in CAD+simple PAD, and highest cadmium burden in the most severe form of PAD – CLI.